This medical condition is a form of autoimmune skin disorder. The cause of lupus is unknown, and the disease usually takes one of two forms. Lupus is the latin word for wolf and has been used to name various skin diseases at least since the 10 th century. Lupus erythematosus le is a chronic, autoimmune disease that includes a broad spectrum of symptoms. Aug 30, 2017 discoid lupus discoid lupus erythematosus is a chronic autoimmune disease affecting the skin. Here, we report the case of a 39yearold man with onset of cutaneous discoid lupus erythematosus during subcutaneous administration of the il17a. It is classified as either localised, affecting skin above the neck only, or generalised, affecting above and below the neck. Discoid lupus discoid lupus erythematosus is a chronic autoimmune disease affecting the skin. The typical presentation of dle is wellcircumscribed, indurated, sometimes scaly round or oval plaques with pigmentary change, often red to purple in color. Lupus, technically known as systemic lupus erythematosus sle, is an autoimmune disease in which the bodys immune system mistakenly attacks healthy tissue in many parts of the body. Discoid lupus erythematosus dle is one of several rashes that can occur in lupus. It is a chronic skin condition of sores with inflammation and scarring favoring the face, ears, and scalp and at times on other body areas. Oct 11, 2016 cutaneous lupus erythematosus 3 categories of lespecific skin diseases 1. Discoid lupus erythematosus dle is a common autoimmune skin condition in dogs.
Dermoscopy of discoid lupus erythematosus request pdf. The discoloration can be accompanied by ulcers and bleeding. Objectives to characterize the cytokine profile in dle by immunohistochemical and molecular methods, and to investigate the role of cytokines in the. Discoid lupus erythematosus in dogs dr robert hilton bvschons macvsc canine medicine cert. Cutaneous discoid lupus areas showing depigmentation and erythema should be selected for biopsy, rather than areas of ulceration andor crusts. Dle can cause permanent scarring if treatment is inadequate. Uncommon cutaneous manifestations of lupus erythematosus jm. Pdf download for biological therapies in the treatment of cutaneous lupus. It presents with red, inflamed, coinshaped patches of skin with a scaling and crusty appearance, most often on the scalp, cheeks, and ears. Discoid lupus erythematosus dle is the most common form of cutaneous lupus erythematosus. The word discoid is referring to the lesions disk shape. Cutaneous lupus erythematosus 3 categories of lespecific skin diseases 1. The primary cle subsets are discoid lupus erythematosus dle, subacute cutaneous lupus erythematosus scle, and acute cutaneous lupus erythematosus acle.
Discoid lupus affects only the skin and does not usually involve internal organs. Lupus erythematosus may be of several types including discoid dle and systemic sle. At one end of the range is systemic lupus erythematosus, which can damage internal organs, whilst right at the other end of the range is discoid lupus erythematosus, which is confined to the skin and does not cause general ill health. Discoid lupus erythematosus sri lanka journal of child health. Severe chronic blepharitis and scarring ectropion associated with discoid lupus erythematosus. Jan, 2012 untreated periocular discoid lupus erythematosus dle, though very rare, may lead to significant morbidity with lid deformities, trichiasis, and symblepharon formation. Importance discoid lupus erythematosus dle is a chronic variant of cutaneous lupus erythematosus, an autoimmune inflammatory disorder of the skin. Discoid lupus is less severe and less life threatening, but approximately 5% of the dle patients may develop the systemic type of lupus as well. Article information, pdf download for epidemiology and socioeconomic impact. Discoid lupus erythematosus of the vulva r bilenchi, c. Detection of type 1 cytokines in discoid lupus erythematosus. The propensity of some patients progressing to systemic lupus should be given.
Secukinumabinduced chronic discoid lupus erythematosus. Introduction systemic lupus erythematosus sle is a multi system connective tissue disorder characterized by the presence of. Discoid cutaneous lupus erythematosus vca animal hospital. Cutaneous lupus erythematosus cle is an autoimmune disease with various subsets and wideranging clinical manifestations. Sunscreens, protective clothing and protective makeup including wig. Download as pptx, pdf, txt or read online from scribd. Discoid lupus erythematosus dle is a disfiguring autoimmune skin disease and the most common form of chronic cutaneous lupus erythematosus. About 5%10% of patients with discoid lupus erythematosus will progress to systemic lupus.
Sunscreens, protective clothing and protective makeup including wig are helpful in preventing damage to the skin. Early diagnosis and treatment of discoid lupus erythematosus. Cutaneous lupus erythematosus cle is an autoimmune skin disease occurring in. Gilliam recognized subacute cutaneous lupus erythematosus scle as a lupus specific eruption that identifies a unique subset of lupus erythematosus. If you have discoid lupus, you may develop chronic. Case report of discoid lupus erythematosus in association. It is confined to the skin and does not cause any systemic symptoms. It gets its name from the coinshaped lesions it produces.
Discoid lupus symptoms, diagnosis, treatments and causes. Subacute cutaneous lupus erythematosus sciencedirect. Dle lesions are commonly incited by trauma, infection, burns, dermatitis, and ultraviolet radiation. Aug 21, 2018 discoid lupus erythematosus is known to negatively impact patient quality of life. Discoid lupus erythematosus in the nigerians jacyk. Discoid lupus erythematosus dle is a chronic variant of cutaneous lupus erythematosus characterized by welldefined erythematous plaques with scale, often predominantly featured on the face, ears, anterior neck, and scalp. Skinvet clinic faq discoid lupus erythematosus veterinary. Review of treatment for discoid lupus erythematosus garza. Balance the severity of cutaneous lupus against the risks of therapy. Discoid lupus erythematosus is an uncommon skin rash, usually made worse by exposure to sunlight.
Backgound although multiple studies suggest a dysregulated tcell cytokine production in systemic lupus erythematosus, the cytokine profile in discoid lupus erythematosus dle lesions is unknown objectives to characterize the cytokine profile in dle by immunohistochemical and molecular methods, and to investigate the role of cytokines in the pathogenesis of dle. Discoid lupus erythematosus following herpes zoster. Risk of systemic lupus erythematosus is approximately 5%. The prevalence rates of systemic lupus erythematosus sle may vary within. Discoid lupus erythematosus is a rare skin disease in horses that is believed to be a variant of systemic lupus erythematosus. Its diversity of clinical features is matched by the complexity of the factors genetic, hormonal, and environmental that cause it, and the array of autoantibodies with which it is associated. The first and the foremost step in the treatment of discoid lupus erythematosus is to avoid exposure to sun as individuals with discoid lupus erythematosus can develop sunburns when exposed to sun. Discoid lupus erythematosus an overview sciencedirect topics. The skin around the nose may also look abnormal, and rarely, the. Discoid lupus erythematosus definition of discoid lupus. Acute cutaneous lupus erythematosus acle most commonly presents as symmetric erythema overlying the malar cheeks and nasal bridge with sparing of the nasolabial folds butterfly rash.
In discoid lupus erythematosus, the alopecic area shows active inflammation with erythema, edema, scaling, and follicular plugging, as well as atrophy with variable degrees of telangiectasia and dyspigmentation. Dogs with dle develop crusting and scabbing of the skin, most commonly starting around the nose, as well as a loss of skin pigmentation in the affected area. It has a characteristic clinical appearance consisting of red, scaly plaques with resulting pigmentary changes and scars. Recently, it was also described with interleukin il 17 inhibition. Pdf discoid lupus erythematosus dle is the most common form of chronic cutaneous lupus erythematosus. Discoid lupus causes, symptoms and treatment patient. Discoid lupus pictures, symptoms, treatment, causes 2020. Discoid lupus erythematosus dle may develop on traumatized skin and also may arise at sites of a prior cutaneous eruption. However, there is limited evidence for which treatments are most effective.
Pathology of discoid lupus erythematosus dr sampurna roy md. It has a prolonged course and can have a considerable effect on quality of life. Lupus erythematosus is a chronic inflammatory autoimmune disease with a wide range of clinical manifestations ranging from an indolent chronic cutaneous form to a severe potentially lifethreatening disease, systemic lupus erythematosus discoid lupus erythematosus is a subphenotype of chronic cutaneous lupus erythematosus, characterised by scaly diskshaped plaques which may be localised. Determining risk factors for developing systemic lupus erythematosus in patients with discoid lupus erythematosus.
The term lupus erythematosus is applied to a range of related disorders. Jul 31, 2018 discoid lupus erythematosus is confined to the skin and is not associated with symptoms from other organs. Discoid lupus erythematosus dle is a skin condition of dogs. Discoid lupus erythematosus dle is an inflammatory autoimmune disease leading to scarring and hair loss. It typically causes a loss of color in the hairless, moist part of the nose. Dle is different from systemic lupus erythematosus sle, the most common form of lupus, which can affect any part of the body.
Pdf to determine the demographic data, clinical pattern and therapeutic. Feb 22, 2016 discoid lupus erythematosus dle is a chronic photosensitive skin eruption which can be either localised or widespread. Discoid lupus erythematosus dle is a chronic cutaneous disease characterized by inflammatory plaques that, in the absence of prompt diagnosis and treatment, may lead to disfiguring scarring and skin atrophy. The isomorphic response is the appearance of new lesions from a preexisting skin condition at a site of trauma.
We present a unique case of discoid lupus erythematosus in which cluster of differentiation 68 cd68 immunochemistry identified widely dispersed histiocytes. Clinical characteristics of each group are unique 8. Discoid lupus erythematosus british association of. Epidemiology and socioeconomic impact of skin disease in lupus. A more severe form is called systemic lupus erythematosus sle, which can affect internal organs. Lupus, in general, is a medical condition that causes your bodys immune system to attack. Discoid lupus erythematosus dle, also known as cutaneous lupus erythematosus, is an autoimmune disease that affects the skin, in which the bodys own immune system is activated to attack the body. Background we report the clinical and histopathological features of discoid lupus erythematosus dle in a group of saudi patients, and provide a basic framework for a. Common symptoms include painful and swollen joints, fever, chest pain, hair loss, mouth ulcers, swollen lymph nodes, feeling tired, and a red rash which is. Lupus erythematosus le is a common autoimmune disease that manifests in systemic and cutaneous forms. In fact, a 2016 study demonstrated that over one third of patients with cutaneous lupus met criteria for depression or anxiety with need for psychiatric intervention.
Although dle usually responds to topical or intralesional corticosteroids andor oral antimalarials, some dle is resistant to. The lesions are typically chronic scaly plaques on the face, scalp and ears. Other articles where discoid lupus erythematosus is discussed. Clinically, the lesions appear as diskshaped plaques surmounted by a white adherent scale that also involves the hair follicles. Systemic lupus erythematosus larissa lisnevskaia, grainne murphy, david isenberg systemic lupus erythematosus is a remarkable and challenging disorder.
Discoid lupus erythematosus is confined to the skin and is not associated with symptoms from other organs. It has been described as part of systemic lupus erythematosus sle or in isolation in adults1. Druginduced lupus erythematosus is a rare adverse event of biological treatment, mainly observed with tumor necrosis factor. The diagnosis is usually made by clinical examination. The term discoid refers to a rash of distinct reddened patches covered with grayish brown scales that may appear on the face, neck, and scalp. The term cutaneous lupus erythematosus is applied to.
Discoid lupus erythematosus dle is a chronic skin condition that occurs in the face, ears. Discoid lupus erythematosus is an uncommon skin rash. Discoid lupus is an autoimmune disease where the immune system attacks the skin. Cutaneous lupus erythematosus cle can be divided into 3 main subtypes. We report the case of a 20yearold woman with a history of systemic lupus erythematosus sle and dle who developed a painful, multidermatomal, vesicular rash. The lesions of discoid lupus erythematosus dle are categorized as either localized presenting above the neck in the scalp, face, and ears, or generalized involving areas above and below the neck, often in the upper extremities. On the other hand, many sle patients may present symptoms of. Untreated periocular discoid lupus erythematosus dle, though very rare, may lead to significant morbidity with lid deformities, trichiasis, and symblepharon formation. Article information, pdf download for uncommon cutaneous manifestations of lupus. Clinically, the lesions appear as diskshaped plaques surmounted by a. Discoid lupus erythematosus following herpes zoster mdedge. Nov 28, 2019 discoid lupus erythematosus dle is a form of lupus that mainly affects your skin.
Discoid lupus erythematosus an overview sciencedirect. Females are more often affected, and the disease is more common in african american women. Microsoft powerpoint discoid lupus erythematosus in dogs. Request pdf dermoscopy of discoid lupus erythematosus summary background dermoscopy is useful in evaluating skin tumours, but its applicability also extends into the field of inflammatory skin. Lupus erythematosus le is a group of diverse, persistent inflammatory autoimmune diseases and often affects the skin. Discoid lupus erythematosus dle and subacute cutaneous lupus erythematosus scle are variants of cutaneous lupus that may occur independently or as manifestations of systemic lupus erythematosus. At one end of the range is systemic lupus erythematosus, which can. Early recognition and treatment improves the prognosis.
We report a case of severe haemolytic anaemia with discoid lesions. Discoid lupus erythematosus in the nigerians jacyk 1979. Treatment of alopecia in chronic cutaneous lupus erythematosus. Dle discoid lupus collie nose what is discoid lupus. Druginduced scle and drug induced chronic cutaneous lupus. Cutaneous manifestations of lupus erythematosus le are, usually. The disease called discoid lupus erythematosus only affects the skin, although similar discoid skin lesions can occur in the serious disease called systemic lupus erythematosus sle. Biological therapies in the treatment of cutaneous lupus. Affected horses develop areas of patchy erythema, crusting alopecia, and scaling on the face, ears, and neck.
It is relatively easy to diagnose and is also treatable. Review of treatment for discoid lupus erythematosus. Patients with chronic discoid lupus erythematosus constituted 046% of all out. Discoid lupus erythematosus, the most common form of chronic cutaneous lupus erythematosus, is a disease of great clinical importance, characterized by the presence of erythematous, atrophic and. Genital involvement is a rare manifestation in discoid lupus erythematosus dle and systemic lupus erythematosus sle, and there are few reports on vulvar clinical features. Discoid lupus erythematosus dle is a form of lupus erythematosus marked by chronic skin eruptions. A preponderance of females was noticed femalemale ratio of 5. Discoid lupus erythematosus is the most common type of chronic cutaneous lupus ccle, an autoimmune skin condition on the lupus erythematosus spectrum of illnesses. Discoid lupus erythematosus is a chronic dermatological disease that can lead to scarring, hair loss, and hyperpigmentation changes in skin if it is not treated early and promptly. Aug 21, 2018 cutaneous lupus erythematosus cle can be divided into 3 main subtypes. Discoid lupus erythematosus in dogs symptoms, causes. Discoid lupus erythematosus dle is a relatively common form of chronic cutaneous lupus, although its presentation in children is rare.
Discoid lupus erythematosus dle is the most common chronic form of cutaneous lupus. The histologic profile of discoid lupus erythematosus typically involves a vacuolar interface reaction with an associated superficial and deep perivascular infiltrate composed of lymphoplasmacytes. Lesions are often localized to the scalp and can result in permanent scarring, disfiguration, and irreversible alopecia. Dle most commonly occurs on the head and is characterized by welldefined inflammatory plaques that evolve into atrophic, disfiguring scars. Symptoms will be mostly in his nasal area but can also impact other areas of his face and head. Only about 10% of all patients with dle will go on to develop the multiorgan disease sle. Le is included among the so called connective tissue diseases and is divided into one systemic form sle and one cutaneous form cle. Symptoms vary between people and may be mild to severe.
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